MNMR Center

Satelite NMR Labs being in charge

(click each tab to see its information)

  • ITDD 4001
  • MC 4002
  • CCRB 5002
  • CDD 6003

Insitute for Therapeutic Discovery and Development 400MHz NMR

Resources

The 400 MHz NMR spectrometer, located in the new 717 Building, 717 Delaware SE on the University of Minnesota East Bank Campus, is owned by the UMN Institute for Therapeutic Discovery and Development and maintained by our facility personnel.


The 400 MHz Bruker Avance spectrometer is currently equipped with a BBO broadband probe and a 60-sample autosampler for routine work, and a flow-probe with a Gilson liquids handler for Combinatorial Chemistry analysis.

Access and Billing

The spectrometer is available to all facility users who complete the training procedure. The training request form can be accessed from the "ITDD 4001" menu above. There is an email option on the pdf, but if that isn't working you must save and send the form to Beverly Ostrowski at ostro016@umn.edu.

Hourly Charges for 400 MHz NMR:
prime time: $10/hr. (M-F 10AM-5PM)
off-hours: $5/hr. (M-F 5PM-10AM, Sat/Sun)

BBO Broadband Probe

This probe is designed for the best sensitivity on heteronuclei such as carbon and phosphorous. This probe is equipped for Z-axis gradients.

Medicinal Chemistry 400 MHz NMR

Resources

The 400 MHz MedChem NMR is owned by University of Minnesota Medicinal Chemistry Department and maintained by our facility personnel. The 400 is located in Weaver-Densford Hall on University of Minnesota East Bank.


The 400 MHz spectrometer is equipped with a Varian NMR System console. The 400 MHz spectrometer is currently installed and is equipped with pulsed-field gradients and a dual broadband, autotunable probe.

Access and Billing

The spectrometer is available to all facility users who complete the training procedure. The training request form can be accessed from the "MedChem 4002" menu above. There is an email option on the pdf, but if that isn't working you must save and send the form to Todd Rappe at rapp0006@umn.edu.

Hourly Charges for 400 MHz NMR:
prime time: $10/hr. (M-F 10AM-5PM)
off-hours: $5/hr. (M-F 5PM-10AM, Sat/Sun)

Dual Broadband Probe

Probe signal-to-noise specifications:

1H 250:1;   19F 250:1;   31P 140:1;   13C 165:1

Cancer and Cardiovascular Research Building 500MHz NMR: to be changed

Resources

The CCRB 500 MHz NMR is shared by the Department of Medicinal Chemistry and Masonic Cancer Center. MNMR personnel provide service, support and training to the users. The 500 is located in Cancer and Cardiovascular Research Building (CCRB) which is close to TCF Stadium on University of Minnesota East Bank campus.


The 500-MHz spectrometer is equipped with a Bruker Avance IIIHD console. The spectrometer is a two-channel instrument with z-axis gradient and SampleXpress 60-sample autosampler.

Broadband Observe SmartProbe

This probe delivers high sensitivity on both the multinuclear and proton channel. It uses separate coils for 19F and 1H allowing the ability to observe 19F with 1H decoupling and to perform two-dimensional 1H/19F spectroscopy.

Probe signal-to-noise specifications:

1H 800:1;  19F 600:1;  31P 220:1;  13C 300:1;  15N 50:1

Center for Drug Design 600 MHz NMR

Resources

The 600 MHz CDD NMR is owned by the Center for Drug Design and maintained by our facility personnel. The 600 is located in Phillips Wangensteen Building on University of Minnesota East Bank campus in the Center for Drug Design.


The 600 MHz spectrometer is equipped with a new Varian NMR System console. The spectrometer is a three-channel instrument with triple-axis gradients.

Dual Broadband Switchable Probe

This probe is designed for the best sensitivity on heteronuclei such as carbon and phosphorous. This probe is equipped for Z-axis gradients.

Probe signal-to-noise specifications:

1H 547:1;   19F 598:1;   31P 221:1;   13C 376:1;   15N 49:1

Triple Resonance HCN Probe

This probe is designed for best proton sensitivity for 1-D proton spectra and proton-detected experiments such as COSY, NOESY, and HMQC. This probe is equipped for triple-axis gradients.

Probe signal-to-noise specifications:

1H 1257:1

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