Publications

The following publications by our students and faculty were made possible, in part, by the NMR Facility:

Schreiner, P., Chen, X., Husnjak, K., Randles, L., Zhang, N., Elsasser, S., Finley, D., Dikic, I., Walters, K. J., Groll, M.: "Ubiquitin docking at the proteasome via a novel PH domain interaction," Nature 453, 548-552 (2008).

Husnjak, K., Elsasser, S., Zhang, N., Chen, X., Randles, L., Hofmann, K., Walters, K. J., Finley, D., Dikic, I.: "Proteasome subunit Rpn13 is a novel ubiquitin receptor," Nature 453, 481-488 (2008).

Matthew Devany , Ferdinand Kappes, Kuan-Ming Chen, David M. Markovitz and *Hiroshi Matsuo , "Solution NMR structure of the N-terminal domain of the human protein DEK." Protein Science, (2008), 17, pp205-215. http://www.proteinscience.org/cgi/content/full/17/2/205

Kang, K., Chen, X., Lary, J. W., Cole, J. L., Walters, K. J.: "Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin," J. Mol. Biol. 369, 168-176 (2007).

Wang, Q.; Deloia, M.A.; Kang, Y.; Litchke, C.; Zhang, N.; Titus, M.A.; Walters, K.J., Protein Science, 16, (2007) 189-196.

Kang, Y.; Zhang, N.; Koepp, D.M.; Walters, K.J.; "Ubiquitin Receptor Proteins hHR23a and hPLIC2 Interact", J. Mol. Biol., 365, (2007) 1093-1101.

Aya Kitamura, Paul J Jardine, Dwight Anderson, Shelley Grimes and *Hiroshi Matsuo, "Analysis of intermolecular base pair formation in prohead RNA of the phage ø29 DNA packaging motor using NMR spectroscopy." Nucleic Acids Research, Nucleic Acids Research Advance Access published December 15, 2007. http://nar.oxfordjournals.org/cgi/content/full/36/3/839

Brandie J. Kovaleski, Robert Kennedy, Ahmad Khorchid, Lawrence Kleiman, Hiroshi Matsuo, and *Karin Musier-Forsyth, "Critical role of helix4 of HIV-1 Capsid C-terminal domain in interactions with human Lysl-tRNA sythetase." J. B. C. (2007), Nov 2; 282(44):32274-9. http://www.jbc.org/cgi/content/full/282/44/32274

Mulder, WJ, van der Schaft, DW, Hautvast, PA, Strijkers, GJ, Koning, GA, Storm, G. Mayo, KH, Griffioen, AW, and Nicolay, D. (2007) Early in vivo assessment of angiostatic therapy efficacy by molecular MRI. FASEB J. 21:378-83.

Peterson, A.A.; McNeill, K.; "Catalytic Dehalogenation of sp2 C-F and C-Cl Bonds in Fluoro- and Chloroalkenes", Organometallics, 25(21), (2006) 4938-4940.

Liu, F.; Zhang, N.; Zhou, X.; Hanna, P.E.; Wagner, C.R.; Koepp, D.M.; Walters, K.J.; "Arylamine N-acetyltransferase Aggregation and Constitutive Ubiquitylation" J. Mol. Biol, 361, (2006) 482-492.

Fisher, A.; Mann, A.; Verma, V.; Thomas, N.; Mishra, R.K.; Johnson, R.L.; "Design and Synthesis of Photoaffinity-Labeling Ligands of the L-Prolyl-L-leucylglycinamide Binding Site Involved in the Allosteric Modulation of the Dopamine Receptor", J. Med Chem, 49, (2006) 307-317.

Hecht, S.S.; Huang, C.; Stoner, G.D.; Li, J.; Kenney, P.M.J.; Sturla, S.J.; Carmella, S.G., "Identification of Cyanidin Glycosides as Potential Chemopreventive Constituents of Freeze-Dried Black Raspberries", Carcinogenesis, (2006) in press.

Henry P-G, Marjanska M, Walls JD, Valette J, Gruetter R, Ugurbil K. POCE NMR Spectroscopy in Strongly Coupled Second Order Spin Systems. Magn Reson Med 2006; 55(2):250-257

Dinesh Kumar Deelchand, Kamil Ugurbil, Pierre-Gilles Henry, "Investigating Brain Metabolism at High Fields using Localized 13C NMR Spectroscopy wihtout 1H Decoupling", Magnetic Resonance in Medicine, 55, 279-286 (2006).

Traaseth, J.J., D.D. Thomas and G. Veglia. 2006. Effects of Ser16 phosphorylation on the allosteric transitions of phospholamban/Ca(2+)-ATPase complex. J. Mol. Biol. 358: 1041-50.

Buffy, J.J., B.A. Buck-Koehntop, F. Porcelli, N.J. Traaseth, D.D. Thomas and G. Veglia. 2006. Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopy. J Mol Biol, 358: 420-9.

Kang, Y., Vossler, R.A., Diaz-Martinex, L.A., Winter, N.S., Clarke, D.J., Walters, K.J.; "UBL/UBA Ubiquitin Receptor Proteins Bind a Common Tetraubiquitin Chain", (2006) J. Mol. Biol., 356,1027-1035.

Gong, J.; Neels, J.F.; Yu, X.; Kensler, T.W.; Peterson, L.A.; Sturla, S.J., "Investigating the Role of Stereochemistry in the Activity of Anticancer Acylfulvenes: Synthesis, Reductase-Mediated Bioactivation and Cellular Toxicity, J Med Chem, 49, 2593-2599 (2006).

Nguyen, T.N.T.; Bertagnolli, A.D.; Villalta, P.W.; Buhlmann, P.; Sturla, S.; "Characterization of a deoxyguanosine adduct of tetrachlorobenzoquinone: Dichlorobenzoquinone-1, N2-etheno-2'-deoxyguanosine", J. Chem. Res. Toxicol. 18, 1770-1776.

Sorensen, P.W.; Fine, J.M.; Dvornikovs, V.; Jeffrey, C.S.; Shao F.; Wang, J.; Vrieze, L.A.; Anderson, K.R.; Hoye, T.R. "Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey", (2005) Nature Chem. Biol., 1(6), 324-328.

Buck-Koehntop, B.A., A. Mascioni, et al. (2005). "Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride." J Mol Biol 354(3):652-65.

Wang, Q., Young, P., Walters, K.J., "Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition", (2005) J.Mol. Biol., 348, 727-739. Cover

Gronwald, J.W., Plaisance, K.L., Marimanikkuppam, S., Ostrowski, B.G., "Tagetitoxin Purification and Partial Characterization", (2005) Physiological and Molecular Plant Pathology, 67, 23-32.

Somu, R.V., Johnson, R.L., "Synthesis of Pipecolic Acid-Based Spiro Bicyclic Lactam Scaffolds as b-Turn Mimics", (2005) Journal of Organic Chemistry, 70,5954-63.

Sturla, S. J., Scott, J., Lao, Y., Hecht, S.S., Vilalta, P.W., "Mass Spectrometric Analysis of Relative Levels of Pyridyloxobutylation Adducts Formed in the Reaction of DNA with a Chemically Activated Form of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)", (2005) Chem. Res. Toxicol., in press.

Devany, M.; Matsuo, H., "NMR Resonance assignments for the DNA-supercoiling domain of the human protein DEK" [Letter] (2005), Journal of Biomolecular NMR, 31(1), 65.

Devany, M.; Kotharu, N.P.; Matsuo, H.; "Expression and isotopic labeling of structural domains of the human protein DEK", (2005) Protein Expression and Purification, 40, 244-247.

Metcalfe, E.E.; Traaseth, N.J.; Veglia, G.; "Serine 16 Phosphorylation Induced an Order-to-Disorder Transition in Monomeric Phospholamban", (2005) Biochemistry, 44, 4386-4396.

Zamoon, J., Nitu, F., Karim, C., Thomas, D.D., Veglia, G., "Mapping the interaction surface of a membrane protein: Unveiling the conformational switch of phospholamban in calcium pump regulation", (2005) PNAS, 102, 4747-4752.

Metcalfe, E.E., Traaseth, N.J., Veglia, G., "Serine 16 Phosphorylation Induces an Order-to-Disorder Transition in Monomeric Phospholamban", (2005) Biochemistry, 44, 4386-4396.

Orsini, MJ, Nesmelova, I., Young, H.C., Hargittai, B., Beavers, M.P., Liu, J., Connolly, P.J., Middleton, S.A., Mayo, K.H., "The Nociceptin Pharmacophore Site for Opioid Receptor Binding Derived from the NMR Structure and Bioactivity Relationships" (2005) Journal of Biological Chemistry, 280, 8134-8142.

Nesmelova, I.V., Sham, Y., Dudek, A.Z., van Eijk, L.I., Wu, G., Slungaard, A., Mortari, F., Griffioen, A.W., Mayo, K.H., "Platelet Factor 4 and Interleukin-8 CXC Chemokine Heterodimer Formation Modulates Function at the Quaternary Structural Level", (2005) Journal of Biological Chemistry, 280, 4948-4958.

Hummel MA, Gannett PM, Aguilar JS, Tracy TS. "Effect-Mediated Alteration of Substrate Orientation in Cytochrome P450 2C9." Biochemistry, 43, 7207-7214.

Wang, Q., Walters, K.J., "Chemical Shift assignments of the (poly)ubiquitin-binding region of the proteasome subunit S5a", (2004) J.Biomol.NMR, 30, 231-232.

Oz, G.; Berkich, D.A.; Henry, P.G.; Xu, Y.; LaNoue, K.; Hutson, S.M.; Gruetter, R.; "Neuroglial metabolism in the awake rate brain: CO2 fixation increases with brain activity", J. Neurosci., 24, 11273-11279.

Porcelli, F., Buck, B., L, D.-K, Hallock, K.J., Ramamoorthy, A., Veglia, G., "Structure and Orientation of Pardaxin Determined by NMR Experiments in Model Membranes", (2004) Journal of Biological Chemistry, 279, 45815-45823.

Idiyatullin, D., Daragan, V.A., Mayo, K.H., "A simple method to measure 13CH2 heteronuclear dipolar cross-correlation spectral densities", (2004) Journal of Magnetic Resonance, 171, 4-9.

Nesmelova, I.V., Idiyatullin, D., Mayo, K.H., "Measuring protein self-diffusion in protein-protein mixtures using a pulsed gradient spin-echo technique with WATERGATE and isotope filtering", (2004) Journal of Magnetic Resonance, 166, 129-33.

Lockwood, N.A., Haseman, J.R., Tirrell, M.V., Mayo, K.H., "Acylation of SC4 dodecapeptide increases bacterial potency against Gram-positive bacteria, including drug-resistant strains", (2004) Biochem. J., 378, 93-103.

Tulla-Puch, J., Getun, I.V., Woodward, C., Barany, G., "Native-like conformations are sampled by partially folded and disordered variants of bovine pancreatic trypsin inhibitor", (2004) Biochemistry, 43, 1591-8.

Balcome, S., Park, S., Quirk Dorr, D.R., Hafner, L., Phillips, L., Tretyakova, N., "Adenine-containing DNA-DNA cross-links of antitumor nitrogen mustards", (2004)Chemical Research in Toxicology, 17, 950-62.

Park, S., Tretyakova, N., "Structural characterization of the major DNA-DNA crosslink of 1,2,3,4-diepoxybutane", (2004) Chemical Research in Toxicology, 31, 1984-94.

Cobine, P.A.; McKay, R.T.; Zangger, K.; Dameron, C.T.; Armitage, I.M.; "Solution structure of Cu6 metallothionein from the fungus Neurospora crassa", (2004) Eur. J. Biochem, 271, 4213-4221.

Xu, Y.; Oz, G.; LaNoue, K.F.; Keiger, C.J.; Gruetter, R.; Hutson, S.H.; "Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: effects of gabapentin", (2004) J Neurochem, 90(5), 1104-16.

Devany, M.; Kotharu, N.P.; Matsuo, H.; "Solution NMR structure of the C-terminal domain of the human protein DEK", (2004) Protein Science, 13, 2252-2259.

Metcalfe, E.E.; Zamoon, J.; Thomas, D.D.; Veglia, G.; "1H/15N Heteronuclear NMR Spectroscopy Shows Four Dynamic Domains for Phospholamban Reconstituted in Dodecylphosphocholine Micelles.", (2004) Biophys. J, 87:1205-1214.

Buck, B.A., Mascioni, A., Cramer, C.J., Veglia, G.; "Interactions of Alkyltin Salts with Biological Dithiols: Dealkylation and Induction of a Regular Beta-Turn Structure in Peptides", (2004) JACS, 126, 14400-14410.

Henry, P.-G.; Oz, Gulin; Provencher, S.; Gruetter, R.; "Toward dynamic isotopomer analysis in the rat brain in vivo: automatic quantitation of 13C NMR spectra using LCModel", (2003) NMR in Biomedicine, 16, 400-412.

Zamoon, J.; Mascioni, A.; Thomas, D.D.; Veglia, G.; "NMR Solution structure and topological orientation of monomeric phospholamban in dodecylphosphocholine micelles", (2003) Biophys J., 85, 2589-2598.

Buck, B.; Zamoon, J.; Kirby, T.L.; DeSilva, T.M.; Karim, C.B.; Thomas, D.D.; Veglia, G.; "Overexpression, purification and characterization of recombinant Ca-ATPase regulators for high-resolution solution and solid-state NMR studies.", (2003) Protein Expr. Purif., 30, 253-261.

Wang, Q.; Goh, A.M.; Howley, P.M.; Walters, K.J.; "Ubiquitin Recognition by the DNA Repair Protein hHR23a", (2003) Biochemistry, 42, 13529-13535.

Walters, K.J.; Lech, P.J.; Goh, A.M.; Wang, Q.; Howley, P.M.; "DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a", (2003) PNAS, 100, 12694-12699.

Dings, R.P.M.; Arroyo, M.; van Eijk, L.; Grieffioen, A.W.; Mayo, K.H.; "ß-Sheet is the Bioactive Conformation of the Anti-Angiogenic Peptide Anginex", (2003) Biochem. J., in press

Dudek, A.Z.; Nesmelova, I.; Mayo, K.H.; Verfaillie, C.M.; Pitchford, E.; Slungaard, A.; "Platelet Factor 4 Promotes Adhesion of Hematopoietic Progenitor Cells and Binds IL-8: Novel Mechanisms for Modulation of Hematopoiesis", (2003) Blood, (in press).

Dings, R.P.M.; Grieffioen, A.; Mayo, K.H.; "Discovery and Development of Antiangiogenic Peptides: a Structural Link", (2003) Angiogenesis, in press.

Idiyatullin, D.; Daragan, V.A.; Mayo, K.H.; "¹⁵NH Bacbone Dynamics of Protein GB1: Comparison of Order Parameters and Correlation Times Derived using Various 'Model Free' Approaches"; (2003) J. Phys. Chem., 107, 2602-2609. .

Grieffioen, A.; Mayo, K.H.; "Designing ßpep Peptides: A Rational Approach to Discovery of Novel Pharmaceutical Agents and Small Molecules", (2003), Drugs of the Future, in press.

Idiyatullin, D.; Nesmelova, I.; Daragan, V.A.; Mayo, K.H.; "Comparison of ¹³Calpha H ¹⁵NH Backbone Dynamics in Protein GB1", (2003) Protein Science, 12, 912-922.

Dings, R.P.M.; Hargittai, B.; Haseman, J.; Grieffioen, A.W.; Mayo, K.H.; "Anti-tumor activity of the novel angiogenesis inhibitor anginex", (2003) Cancer Letters, 194, 55-66.

Idiyatullin, D.; Daragan, V.A.; Mayo, K.H.; "Protein Dynamics using Frequency-Dependent Order Parameters from Analysis of NMR Relaxation Data", (2003) J. Magn. Reson., 161, 118-125.

Dings, R.P.M.; Yokoyama, Y.; Ramakrishnan, S.; Griffioen, A.W.; Mayo, K.H.; "The designed angiostatic peptide anginex synergistically improves chemotherapy and anti-angiogenesis therapy with angiostatin", (2003) Cancer Res., 63, 382-385.

Idiyatullin, D.; Nesmelova, I.; Daragan, V.A.; Mayo, K.H.; "Heat Capacities and a Snapshot of the Energy Landscape in Protein GB1 from the Pre-Denaturation Temperature Dependence of Backbone NH Nanosecond Fluctuations", (2003) J.Mol.Biol., 325, 149-162.

Lockwood, N.; van Tankeren, R.; McKernan, S.; Mayo, K.H.; "Aqueous Gel Derived from the ß-Sheet Domain of Platelet Factor-4", (2002) Biomacromolecules, 3, 1225-1232.

van der Schaft, Dings, R.P.M.; de Lussanet, Q.R.; van Eijk, L.I.; Nap, A.W.; Beets-Tan, R.G.H.; Bouma-Ter Steege, J.C.A.; Wagstaff, J.; Mayo, K.H.; Griffioen, A.W.; "The Designer Antiangiogenic Peptide Anginex Targets Tumor Endothelial Cells and Inhibits Tumor Growth in Animal Models", (2002) FASEB Journal, 16, 1991-1993.

van der Schaft, D.W.J.; Wagstaff, J.; Mayo, K.H.; Griffioen, A.W.; "The Antiangiogeneic Properties of Bactericidal/Permeability Increasing Protein (BPI)", (2002) Annals of Medicine, 34, 19-27.

Coltart, D.M.; Royyuru, A.K.; Williams, L.J.; Glunz, P.W.; Sames, D.; Kuduk, S.D.; Schwarz, J.B.; Chen, X.-T.; Danishefsky, S.J.; Live, D.H.; "Principles of Mucin Architecture: Structural Stuies on Synthetic Glycopeptides Bearing Clustered Mono-, Di-, Tri-, and Hexassaccharide Glycodomains", (2002) Journal of the American Chemical Society, 124, 9833-9844.

Barbeau, K.; Zhang, G.; Live, D.H.; Butler, A.; "Petrobactin, a Photoreactive Siderophore Produced by the Oil-Degrading Marine Bacterium Marinobacter hydrocarbonoclasticus", (2002) Journal of the American Chemical Society, 124, 378-379.

Kallick, D.A.; Nagan, M.C.; Beuning, P.J.; Kerimo, S.; Tessmer, M.R.; Cramer, C.J.; Musier-Forsyth, K.; "Discrimination of C1:G72 microhelixAla by AlaRS is based on specific atomic groups rather than conformational effects: An NMR and MD analysis", (2002) Journal of Physical Chemistry B, 106, 8878-8884 .

Battiste, J.L.; Li, R.; Woodward, C.; "A Highly Destablizing Mutation, G37A, of the Bovine Pancreatic Trypsin Inhibitor Retains the Average Native Conformation but Greatly Increases Local Flexibility", (2002) Biochemistry, 41, 2237-2245.

Li, R.; Battiste, J.L.; Woodward, C.; "Native-like Interactions Favored in the Unfolded Bovine Pancreatic Trypsin Inhibitor Have Different Roles in Folding", (2002) Biochemistry, 41, 2246-2253.

Wu, M.; Simpson, C.D.; Christiani, D.C.; Hecht, S.S.; "Relationship of exposure to coke-oven emission and urinary metabolites of benzo[a]pyrene and pyrene in coke-oven workers", (2002) Cancer Epidemiol. Biomarkers & Prev., 11, 311-314.

Mascioni, A.; Karim, C.; Barany, G.; Thomas, D.D.; Veglia, G.; "Structure and Orientation of Sarcolipin in Lipid Environments", (2002) Biochemistry, 41, 475-482.

Wang, M.; McIntee, E.J.; Cheng, G.; Shi, X.; Villalta, P.W.; Hecht, S.S.; "A Schiff base is a major DNA adduct of crotonaldehyde", (2001) Chem. Res. Toxicol., 14, 423-430.

Upadhyaya, P.; McIntee, E.J.; Hecht, S.S.; "Preparation of pyridine-N-glucuronides of tabacco-specific nitrosamines", (2001) Chem. Res. Toxicol., 14, 555-561.

Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.E.; Villalta, P.W.; Hecht, S.S.; "Reactions of 2,6-dimethyl-1,3-dioxane-4-ol (aldoxane) with deoxyguanosine and DNA", (2001) Chem. Res. Toxicol., 14, 1025-1032.

Wiedmann, T.S.; Herrington, H.; Deye, C.; Kallick, D.; "Interaction of sodium taurocholate and egg phosphatidylcholine aggregates in rat intestinal mucin", (2001) Pharm. Res., 18, 1489-1496.

Wiedmann, T.S.; Herrington, H.; Deye, C.; Kallick, D.; "Analysis of the diffusion of bile salt/phospholipid micelles in mucin", (2001) Chem. Phys. Lipids, 112, 81-92.

Barbar, E.; Hare, M.; Makokha, M.; Barany, G.; Woodward, C.; "NMR-Detected Order in Core Residues of Denatured Bovine Pancreatic Trypsin Inhibitor", (2001) Biochemistry, 40, 9734-9742.

Oz, G.; Zangger, K.; Armitage, I.; "Three-dimensional Structure and Dynamics of a Brain specific Growth Inhibitory Factor: Metallothionein-3", (2001) Biochemistry, 40, 11433-11441.

Bozzi, M.; Veglia, G.; Paci, M.; Sciandra, F.; Giardina, B.; Brancaccio, A.; "A synthetic peptide corresponding to the 550-585 region of alpha-dystroglycan binds beta-dystroglycan as revealed by NMR spectroscopy", (2001) FEBS Letters, 24979, 1-5.

Idiyatullin, D.; Daragan, V.A.; Mayo, K.H.; "A New Approach to Visualizing Spectral Density Functions and Deriving Motional Correlation Time Distributions: Applications to an alpha-Helix-Forming peptide and to a Well-Folded Protein", (2001) Journal of Magnetic Resonance, 152, 132-148.

Cox, A.; Arroyo, M.; Mayo, K.H.; "Effects on Folding and Self-Association from Substitution of Hydrophobic Residues at the Beta-Sheet Sandwich Interface of Bpep-4", (2001) Biochem.J., 357, 739-747.

Chang, S.L.; Wallar, B.J.; Lipscomb, J.D.; Mayo, K.H.; "Residues in Methylosinus trichosporium OB3b Methane Monoxygenase Component B Involved in Molecular Interactions with Reduced- and Oxidized-Hydroxylase Component: a Role for the N-Terminus", (2001) Biochemistry, 40(32), 9539-9551.

Idiyatullin, D.; Daragan, V.A.; Mayo, K.H.; "Improved Measurement of 15N-{1H} NOEs in the Presence of NH-Water Proton Chemical Exchange", (2001) J. Magn. Reson., 153, 138-143.

Zangger, K.; Armitage, I.M.; "Dynamics of Interdomain Interactions in Mammalian Metallothioneins", (2001) J.Inorg. Biochem., 88, 135-143.

Zangger, K.; Shen, G.; Oz, G.; Otvos, J.D.; Armitage, I.M.; "Oxidative Dimerization in Metallothionein is a Result of Intermolecular Disulfide Bonds between Cysteines in the alpha-Domain", (2001) Biochem. J., 359, 353-360.

Wiedmann, T.S.; Deye, C.; Kallick, D.; "Interaction of bile salt and phospholipids with bovine submaxillary mucin", (2001) Pharmaceutical Research, 18, 45-53.

Nesmelova, I.; Krusheknitsky, A.; Idiyatullin, D.; Blanco, F.; Ramirez-Alvarado, M.; Daragan, V.A.; Serrano, L.; Mayo, K.H.; "Conformational Exchange on the Microsecond Time Scale in alpha-Helix and Beta-Hairpin Peptides Measured by 13C-NMR Transverse Relaxation", (2001) Biochemistry, 40, 2844-2853.

Beavers, M.P.; Gunnet, J.W.; Hageman, W.; Miller, W.; Moore, J.B.; Zhou, L.; Chen, R.; Xiang, A.; Urbanski, M.; Combs, D.W.; Mayo, K.H.; Peterson, P.A.; Demarest, K.T.; "Discovery of the First Non-Peptide Antagonist of the Motilin Receptor", (2001) Drug Design & Discovery, 17, 243-251.

Griffioen, A.W.; van der Shaft, D.; Barandsz-Janson, A.; Cox, A.; Struijker-Boudier, H.A. Hillen, H.F.P.; Mayo, K.H.; "Anginex, a designed Peptide that Inhibits Angiogenesis", (2001) Biochem. J., 354, 233-242.

He, M.; Sheldon, P.J.; Sherman, D.H.; "Characterization of a quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein", (2001) Proc. Natl. Acad. Sci., 98, 926-931.

Arlandson, M.; Decker, T.; Roongta, V.A.; Bonilla, L.; Mayo, K.H.; MacPherson, J.C.; Hazen, S.L.; Slungaard, A.; "Eosinophil Peroxidase Oxidation of Thiocyanate", (2001) Journal of Biological Chemistry, 276, 215-224.

Wang, M.; McIntee, E.J.; Cheng, G.; Shi Y.; Villalta, P.W.; Hecht, S.S.; "Identification of paraldol-deoxyguanosine adducts in DNA reacted with crotonaldehyde",(2000) Chem. Res. Toxicol., 13, 1065-1074.

Hecht, S.S.; Hochlater, J.B.; Villalta, P.W.; Hecht, S.S.; "2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogenic precursor", (2000) Proc. Natl. Sci., 97, 12493-12497.

Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S.; "Identification of DNA Adducts of Acetaldehyde", (2000) Chem. Res. Toxicol., 13, 1149-1157.

Okar, D.A.; Live, D.H.; Devany, M.H.; Lange, A.J.; "Mechanism of the Biphosphatase Reaction of 6-Phosphofructo-2-kinase/Fructose-2,6-Biphosphatase Probed by 1H-15N NMR Spectroscopy", (2000) Biochemistry, 39, 9654-9762.

Mayo, K.H., "Recent Advances in the Design and Construction of Synthetic Peptides: for the Love of Basics or just for the Technology of it", (2000) Trends in Biotechnology, 18, 212-217.

Daragan, V.A.; Voloshin, A.M.; Chochina, S.V.; Khazanovich, T.N.; Wood, W.G.; Avdulov, N.A.; Mayo, K.H.; "Specific Binding of Ethanol to Cholesterol", (2000) Biophysical J., 79, 406-415.

Mayo, K.H.; Haseman, J.; Young, H.C.; Mayo, J.W.; "Structure-Function Relations in Novel Peptide Dodecamers with Broad Spectrum Bactericidal and Endotoxin Neutralizing Activities", (2000) Biochem. J., 349, 717-728.

Van der Schaft, D.; Toebes, E.A.H.; Haseman, J.R.; Mayo, K.H.; Griffioen, A.W.; "Bactericidal/Permeability-Increasing Protein (B/PI) Inhibits Angiogenesis via Induction of Apoptosis in Vascuular Endothelial Cells", (2000) Blood, 96, 176-181.

Zangger, K.; Armitage, I.M.; "The Accordian-HMQC: Heteronuclear Correlations Over a Range of Coupling Constants", J. Magn. Reson., 38, 452-458.

Mayo, K.H.; Daragan, V.A., Idiyatullin, D.; Nesmelova, I.; "Peptide internal motions on nanosecond time scale from direct fitting of 13C- & 15N-NMR spectral density maps", (2000) J.Mag.Reson., 146, 188-195.

Idiyatullin, D.; Krusheknitsky, A.; Nesmelova, I.; Blanco, F.; Daragan, V.A.; Serrano, L.; Mayo, K.H.; "Internal motional amplitudes and correlated bond rotations in an alpha-helix peptide derived from 13C- and 15N-NMR relaxation", (2000) Protein Science, 9, 2118-2127.

Carulla, N.; Woodward, C.; Barany, G.; "Synthesis and characterization of a b-hairpin peptide that represents a 'core module' of bovine pancreatic trypsin inhibitor (BPTI)", (2000) Biochemistry, 39(27), 7927-7937.

Wang, M.; McIntee, E.J.; Cheng, G.; Shi, Y.; Villalta, P.; Hecht, S.S.; "Identification of Paraldol-Deoxyguanosine Adducts in DNA Reacted with Crotonaldehyde", (2000) Chem. Res. Toxicol., 13, 1065-1074.

Hogenkamp, H.P.C.; Collins, D.A.; Live, D.; Benson, L.M.; Naylor, S.; "Synthesis and Characterization of nido-Carborane-Colbalamin Conjugates", (2000) Nuclear Medicine & Biology, 27, 89-92.

Paterlini, M.G.; Avitable, F.; Ostrowski, B.G.; Ferguson, D.M.; Portoghese, P.S.; "Stereochemical requirements for receptor recognition of the opiod peptide endomorphin-1", (2000), Biophysical Journal, 78, 590-599.

Zangger, K.; Oz, G.; Armitage, I.M.; "Re-evaluation of the Binding of ATP to Metallothionein", (2000)J. Biol. Chem., 275, 7534-7538.

Beuning, P.J.; Tessmer, M.R.; Baumann, C.G.; Kallick, D.A.; Musier-Forsyth, K.; "Sequence Dependent Conformational Differences of Small RNAs Revealed by Native Gel Electrophoresis", Analytical Biochemistry, 273, 284-290 (1999).

Chang, S.-L.; Waller, B.J.; Lipscomb, J.D.; Mayo, K.H.; "Solution Structure of Component B from Methan Monooxygenase Derived Through Heteronuclear NMR and Molecular Modeling", Biochemistry, 38, 5799-5812 (1999).

Daragan, V.A.; Mayo, K.H.; "Using the Model Free Approach to Analyze NMR Relaxation Data in Cases of Anisotropic Molecular Diffusion", J. Phys. Chem., 103, 6829-6834 (1999).

Griffioen, A.; Damen, C.; Marinotti, S.; Blijham, G.; Groenewegen, G.; Mayo, K.H.; "Angiogenesis Inhibitors Overcome Tumor-Induced Endothelial Cell Anergy", Int. J. Cancer, 80, 315-319 (1999).

Hwang, T.-L.; van Zijl, P.C.M.; Garwood, M.; "Asymmetric adiabatic pulses for NH selection", Journal of Magnetic Resonance, 138, 173-177 (1999).

Klaus, W.; Labhardt, A.; Buchwald, P.; Hunziker, W.; Kallick, D.A.; "Secondary structural elements of calbindinD28 I,II as determined by multinuclear and multidimensional NMR", European Journal of Biochemistry, 262, 933-938 (1999).

Live, D.H.; Williams, L.J.; Kuduk, S.D.; Schwarz, J.B.; Glunz, P.W.; Chen, X.-T.; Sames, D.; Kumar, R.A.; Danishefsky, S.J.; "Probing cell-surface architecture through synthesis: An NMR-determined structural motif for tumor-associated mucins", Proceedings of the National Academy of Science, 96, 3489-3493(1999).

Mikhailov, D.V.; Young, H.; Lindhardt, R.J.; Mayo, K.H.; "Heparin Dodecasaccharide Binding to Platelet Factor-4 and Growth-related Protein-alpha: Induction of a Partially Folded State and Implications for Heparin-Induced Thromnocytopenia", J.Biol. Chem., 274, 25317-25329 (1999).

Mikhailov, D.V.; Washington, L.; Voloshin, A.M.; Daragan, V.A.; Mayo, K.H.; "Angular Variances for Internal Bond Rotations of Side-Chains in GXG-Based Tripeptides derived from 13C-NMR Relaxation Measurements", Biopolymers, 49, 373-383 (1999).

Okar, D.A.; Live, D.H.; Kirby, T.L.; Karschinia, E.J.; von Weymarn, L.B.; Armitage, I.M.; Lange, A.J.; "Mutational Analyses of the histidine residues in the bisphosphatase domain of the rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by NMR spectroscopy reveal that Glu-327 and His-446 participate in a network of hydrogen bonds that includes the catalytic site", Biochemistry, 38, 4471-4479, (1999).

Young, H.; Roongta, V.; Daly, T.J.; Mayo, K.H.; "NMR Structure and Dynamics of Monomeric Neutrophil Activating Peptide-2", Biochem. J., 338, 591-598 (1999).

Yu, Y.-C.; Roongta, V.; Daragan, V.A.; Mayo, K.H.; Tirrell, M.; Fields, G.B.; "Structure and Dynamics of Peptide-Amphiphiles Incorporating Triple-Helical Proteinlike Molecular Architecture", Biochemistry, 38, 1659-1668 (1999).

Zangger, K.; Oz, G.; Otvos, J.D.; Armitage, I.M.; "Three-dimensional solution structure of mouse [Cd7]-metallothionein-1 by homonuclear and heteronuclear NMR spectroscopy", Protein Science, 8, 2630-2638 (1999).

Daragan, V.A.; Mayo, K.H.; "A Simple Approach to Analyzing Protein Side-Chain Dynamics from 13C Relaxation Data", J.Magnetic Resonance, 130, 329-334 (1998).

Griffioen, A.; Barendsz-Janson, A.F.; Mayo, K.H.; Hillen, H.F.P.; "Angiogenesis, a Target for Tumor Therapy", J. Lab. Clin. Med., 132, 363-368 (1998).

Mayo, K.H.; Haseman, J.; Ilyina, E.; Gray, B.H.; "Designed Beta-Sheet-forming Peptide 33mers with Potent B/PI-like Bactericidal and Endotoxin Neutralizing Activities", Biochim. Biophys. Acta, 1425, 81-92 (1998).

Mayo, K.H.; Ilyina, E.; "A Folding Pathway for Betapep-4 Peptide 33mer: From Unfolded Monomers and Beta-sheet Sandwich Dimers to Well-Structured Tetramers", Protein Science, 7, 358-368 (1998).

Ramirez, M.; Daragan, V.A.; Serrano, L.; Mayo, K.H.; "Motional Dynamics of Residues in a Beta-Hairpin Peptide Measured by 13C-NMR Relaxation", Protein Science, 7, 720-729 (1998).

Zangger, K.; Armitage, I.M.; "Sensitivity-enhanced detection of fast exchanging protons by an exchange-edited gradient HEHAHA-HSQC experiment", Journal of Magnetic Resonance, 135, 70-75 (1998).

Daragan, V.A.; Mayo, K.H.; "Motional Model Analyses in Proteins and Peptides using 13C and 15N NMR Relaxation", Progress in NMR Spectroscopy, 31, 63-105 (1997).

Daragan, V.A.; Ilyina, E.; Fields, C.G.; Fields, G.B.; Mayo, K.H.; "Backbone and side-chain dynamics of residues in a partially folded Beta-sheet peptide from PF4", Protein Science, 6, 355-363 (1997).

Ilyina, E.; Roongta, V.; Pan, H.; Woodward, C.; Mayo, K.H.; "A Pulsed-Field Gradient NMR Study of Bovine Pancreatic Trypsin Inhibitor Self-Association", Biochemistry, 36, 3383-3388 (1997).

Ilyina, E.; Roongta, V.; Mayo, K.H.; "NMR Structure of a de Novo Designed Peptide 33mer with Two Distinct, Compact Beta-Sheet Folds", Biochemistry, 36, 5245-5250 (1997).

Ilyina, E.; Roongta, V., Mayo, K.H.; "Designing Water Soluble Beta-Sheet Peptides with Compact Structure", Techniques in Protein Chemistry VIII, 797-808 (1997).

Mayo, K.H.; Fields, G.B.; "Peptides as Models for Understanding Protein Folding", Advances in Molecular and Cell Biology, 22, 565-611 (1997).

Mayo, K.H., "Solution NMR Characterization of Peptide Folding", Methods in Enzymology, 289, 646-672 (1997).

Mayo, K.H., "NMR and X-Ray Studies of Collagen Model Peptides", Biopolymers, 40, 359-370 (1997).

McCornack, M.A.; Kakalis, L.T.; Caserta, C.; Handschumacher, R.E.; Armitage, I.M.; "HIV protease substrate conformation: modulation by cyclophilin A", FEBS Letters, 414, 84-88(1997).

Mikhailov, D.; Linhardt, R.J.; Mayo, K.H.; "NMR Solution Conformation of Heparin-derived Hexasaccharide", Biochemical Journal, 328, 51-61 (1997).

Tessmer, M.R.; Kallick, D.A.; "Role of Tryptophan 14 in Dynorphin A(1-17) in its Interaction with a Model Membrane", International Journal of Peptide and Protein Research, J. Peptide Res., 49, 427-431 (1997).

Tessmer, M.R.; Kallick, D.A.; "NMR and Structural Model of Dynorphin A(1-17) in a Model Membrane", Biochemistry, 36, 1971-1981 (1997).

Tessmer, M.R.; Meyer, J.P.; Hruby, V.; Kallick, D.A.; "Solution Structure of a Potent Cyclic Dynorphin Analog Bound to Micelles", Journal of Medicinal Chemistry, 40, 2148-2155 (1997).

Tessmer, M.R.; Meyer, J.P.; Hruby, V.; Kallick, D.A.; "Solution Structure of a Potent Cyclic Dynorphin Analog Bound to Micelles", Journal of Medicinal Chemistry, 40, 2148-2155 (1997).

Uknis, M.R.; Wasiluk, K.R.; Acton, R.D.; Klaerner, H.G.; Dahlberg, P.S.; Ilyina, E.; Haseman, J.; Gray, B.H.; Mayo, K.H.; Dunn, D.L.; "Design of a Potent Novel Endotoxin Antagonist", Surgery, 122, 380-385 (1997).

Avdulov, N.A.; Chochina, S.V.; Daragan, V.A.; Schroeder, F.; Mayo, K.H.; Wood, W.G.; "Direct Binding of Ethanol to bovine serum albumin: A fluorescent and 13C-NMR Multiplet Relaxation Study", Biochemistry, 35, 340-347 (1996).

Daragan, V.A.; Mayo, K.H.; "Analysis of internally restricted correlated rotations in peptides and proteins using 13C- and 15N-NMR relaxation data", J. Phys. Chem., 100, 8378-8388 (1996).

Daragan, V.A.; Mayo, K.H.; "Analysis of internally restricted correlated rotations in peptides and proteins using 13C- and 15N-NMR relaxation data", J. Phys. Chem., 100, 8378-8388 (1996).

Daragan, V.A.; Mayo, K.H.; "A novel model-free analysis of 13C NMR relaxation of alanine methyl side-chain motions in peptides", J. Mag. Reson., 110, 164-175 (1996).

Mayo, K.; Ilyina, E.; Park, H.; "A Recipe for Designing Water Soluble Beta-Sheet-forming Peptides", Protein Sci., 5, 1301-1315 (1996).

Mayo, K.H.; Fan, F.; Beavers, M.; Eckardt, A.; Keane, P.; Hoekstra, W.; Andrade-Gordon, P., "Integrin Receptor GPIIb/IIIa Bound State Conformation of the Fibrinogen Gamma-Chain C-Terminal Peptide 400-411: NMR and Transfer NOE Studies", Biochemistry, 35, 4434-4444 (1996).

Mayo, K.H.; Fan, F.; Beavers, M.; Eckardt, A.; Kean, P.; Hoekstra, W.; Andrade-Gordon, P.; "RGD induces conformational transition in purified platelet integrin GPIIb/IIIa-SDS system yielding multiple binding states for fibrinogen gamma-chain C-terminal peptide", FEBS Letts, 378, 79-82 (1996).

Mayo, K.H.; an, F.; Beavers, M.; Eckardt, A.; Keane, P.; Hoekstra, W.; Andrade-Gordon, P.; "NOE-derived conformation of GRGDSP cell adhesion recognition site in the presence of SDS micelles and integrin receptor GPIIb/IIIa", Biochim.Biphys. Acta, 1296, 95-102 (1996).

Mikhailov, D.; Mayo, K.H.; Pervin, A.; Linhardt, R.J.; "13C-NMR Relaxation Study of Heparin-Disaccharide Interactions with Tripeptides GRG and GKG", Biochem. J., 315, 447-454 (1996).

Mikhailov, D.; Mayo, K.; Vlahov, I.R.; Toida, T.; Pervin, A.; Lindhardt, R.J.; "NMR Solution Conformation of Heparin-derived Tetrasaccharide", Biochem. J. 318, 93-102 (1996).

Varnum, J.M.; Thakur, M.; Mayo, K.H.; Jansen, S.A.; "Stability and Conformational Analysis of Tc-RC160 and Re-RC160: Experimental and Theoretical Analysis of the Influence of Metal Complexation on the Structural Requisites for Activity", J.Phys.Chem., 100, 14630-14636 (1996).

Yao, L.J.; Mayo, K.H.; "Interactions of integrin GPIIb/IIIa-derived peptides with fibrinogen investigated by NMR spectroscopy", Biochem. J., 315, 161-170 (1996).

Barker, S.; Mayo, K.; "Quarternary Structure Amplification of Protein Folding Differences Observed in 'Native' Platelet Factor-4", FEBS Letts, 357, 301-304 (1995).

Battafarano, R.J.; Dahlberg, P.S.; Ratz, C.A.; Johnston, J.W.; Gray, B.H.; Haserman, B.S.; Mayo, K.H.; Dunn, D.L.; "Peptide derivatives of three distinct lipolysaccharide binding proteins inhibit lipopolysaccharide-induced tumor necrosis factor-alpha Secretion in vitro", Surgery, 118, 318-324 (1995).

Daragan, V.; Mayo, K.; "Using the model free approach to interpret 13C NMR multiplet relaxation data from peptides and proteins", J. Magn. Reson., 107, 274-278 (1995).

Fan, F.; Mayo, K.H.; "Effect of pH on the Conformation and Backbone Dynamics of a 27 Residue Peptide in Trifluoroethanol: An NMR and CD Study", J.Biol.Chem., 270, 24693-24701 (1995).

Gray, B.; Haseman, J.; Mayo, K.; "B/PI-derived Synethetic Peptides: Synergistic Effects in Tethered Bactericidal and Endotoxin Neutralizing Peptides", B.B.A. 1244, 185-190 (1995).

Hoekstra, W.; Bonner, M.P.; Andrade-Gordon, P.; Mayo, K.; Fan, F.; Keane, P.; Durkin, K.; Liotta, D.C.; Kloczewiak, M.; Tomko, K.; Evangelisto, M.F.; Press, J.B.; "Design and Evaluation of Nonpeptide Fibrinogen Gamma Chain Based GPIIB/IIIA Antagonists", J.Med.Chem., 38, 1582-1592 (1995).

Ilyina, E.; Mayo, K.; "Multiple Native-like Conformations Trapped via Self-Association-Induced Hydrophobic Collapse of the 33 Residue Beta-Sheet Domain from Platelet Factor-4", Biochem. J., 306, 407-419 (1995).

Kaboyanski, E.B.; Zhu, C.; Kallick, D.A.; Roth, D.B.; "Hairpin opening by single-strand nucleases", Nucleic Acids Research, 23, 3872-3881 (1995).

Kallick, D.A.; Tessmer, M.R.; Watts, C.R.; Li, C.-Y.; "The Use of Dodecylphosphocholine Micelles in Solution NMR", Journal of Magnetic Resonance, Series B, 109, 60-65 (1995).

Mayo, K.H.; Roongta, V.; Barker, S.; Milius, R.; Ilyina, E.; Quinlan, C.; La Rosa, G.; Daly, T.; "NMR Solution Structure of the 32 kD Tetrameric Platelet Factor-4 ELR-Motif N-terminal Chimer: A Symmetric Tetramer", Biochemistry, 34, 11399-11409 (1995).

Mayo, K.H.; Ilyina, E.; Roongta, V.; Dundas, M.; Joseph, J.; Lai, C.K.; Maione, T.; Daly, T.; "Heparin Binding to Platelet Factor-4. An NMR and Site-Directed Mutagenesis Study: Arginine Residues Crucial for Binding", Biochemical Journal, 312, 357-365 (1995).

Mkhailov, D.; Daragan, V.; Mayo, K.; "13C-Multiplet NMR Relaxation-Derived Ring Puckering and Backbone Dynamics in Proline-Containing Glycine-Based Peptides", Biophyics J., 68, 1540-1550 (1995).

Mikhailhov, D.; Daragan, V.; Mayo, K.; "Lysine Side-Chain Dynamics Derived from 13C Multiplet NMR Relaxation Studies on Di- and Tri-Peptides", J.Biomol.NMR, 5, 397-410 (1995).

Watts, C.R.; Tessmer, M.R.; Kallick, D.A.; "Structure of Leu5-enkephalin bound to a model membrane as determined by high resolution NMR", Letters in Peptide Science, 2, 59-70 (1995).

Watts, C.R.; Kervin, S.; Kuntz, I.D.; Kenyon, G.; Kallick, D.A.; "Rationally designed N, N'-bis[(N-p-guanidinobenzyl-N-methyl)aminocarbonyl] 1,3-diaminobenzene, 'BIGBEN', binds to the minor groove of d(CGCGAATTCGCG)2 as determined by two-dimensional nuclear magnetic resonance spectroscopy', Journal of the American Chemical Society, 117, 9941-9950(1995).

Kallick, D.A., "The Conformation of Dynorphin A(1-17) Bound to Dodecylphosphocholine Micelles", Journal of the American Chemical Society, 115 9317-9318 (1993).

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