Craig Hedberg

Office: 1242 Mayo
Phone: (612) 626-4757

B.S., 1976, Biology, University of Connecticut

M.S., 1984, Environmental Health, University of Minnesota

Ph.D., 1993, Epidemiology, University of Minnesota

Research and Teaching Interests

Foodborne disease surveillance, surveillance of environmental factors associated with foodborne disease, the role of food workers in the occurrence of foodborne diseases, use of epidemiologic methods in outbreak investigations and disease control, environmental contamination with enteric pathogens.

Selected Publications

1. Kuritsky JN, Osterholm MT, Greenberg HB, Korlath JA, Godes JR, Hedberg CW, Forfang JC, Kapikian AZ, McCullough JC, White KE. Norwalk gastroenteritis: A community outbreak associated with bakery product consumption. Ann Intern Med 1984;100:519-21.

2. Hedberg CW, Washburn JW, Sjogren RD. The association of artificial containers and LaCrosse encephalitis in Minnesota, 1979. J Mosq Cont Assoc 1985;1:89-90.

3. MacDonald KL, Osterholm MT, Hedberg CW, Schrock CG, Peterson GF, Jentzen J, Leonard SA, Schlievert PM. Toxic shock syndrome: A newly recognized complication of influenza and influenza-like illness. JAMA 1987;257:1053-8.

4. Hedberg CW, Fishbein DB, Janssen RS, Meyers B, McMiller JM, MacDonald KL, White KE, Huss LJ, Hurwitz ES, Farhie JR, Simmons JL, Braverman LE, Ingbar SH, Schonberger LB, Osterholm MT. An outbreak of thyrotoxicosis caused by the consumption of bovine thyroid gland in ground beef. N Engl J Med 1987;316:993-8.

5. Hedberg CW, Osterholm MT, MacDonald KL, White KE. An interlaboratory study of antibody to Borrelia burgdorferi. J Infect Dis 1987;155:1325-7.

6. Osterholm MT, Rambeck JH, White KE, Jacobs JL, Pierson LM, Neaton JD, Hedberg CW, MacDonald KL, Granoff DM. Lack of efficacy of Haemophilus b polysaccharide vaccine in Minnesota. JAMA 1988;260:1423-8.

7. White KE, Hedberg CW, Edmonson LM, Jones DBW, Osterholm MT, MacDonald KL. An outbreak of giardiasis in a nursing home with evidence for multiple modes of transmission. J Infect Dis 1989;160:298-304.

8. Hedberg K, White KE, Forfang JC, Korlath JA, Friendshus KAJ, Hedberg CW, MacDonald KL, Osterholm MT. An outbreak of psittacosis in Minnesota turkey industry workers: Implications for modes of transmission and control. Am J Epidemiol 1989;130:569-7.

9. Hedberg K, Hedberg CW, Iber C, White KE, Osterholm MT, Jones DBW, Flink JR, MacDonald KL. An outbreak of nitrogen dioxide-induced respiratory illness among ice hockey players. JAMA 1989;262:3014-7.

10. Hedberg K, Ristinen TL, Soler JT, White KE, Hedberg CW, Osterholm MT, MacDonald KL. An outbreak of erythromycin-resistant staphylococcal conjunctivitis in a newborn nursery. J Pediatr Infect Dis 1990;9:268-73.

11. Belongia EA, Hedberg CW, Gleich GJ, White KE, Mayeno AN, Loegering DA, Dunnett SL, Pirie PL, MacDonald KL, Osterholm MT. An investigation into the cause of eosinophilia-myalgia syndrome associated with tryptophan use. N Engl J Med 1990;323:357-65.

12. Mayeno AN, Lin F, Foote CS, Loegering DA, Ames MA, Hedberg CW, Gleich GJ. Characterization of "peak E", a novel amino acid associated with eosinophilia-myalgia syndrome. Science 1990;250:1707-8.

13. Hedberg CW, White KE, Johnson JA, Edmonson LM, Soler JT, Korlath, JA, Theurer LS, MacDonald KL, Osterholm MT. An outbreak of Salmonella enteritidis infection at a fast food restaurant: Implications for foodhandler-associated transmission. J Infect Dis 1991;164:1135-40.

14. Hedberg CW, Korlath JA, D'Aoust J-Y, White KE, Schell WL, Miller MR, Cameron DN, MacDonald KL, Osterholm MT, the Investigation Team. A multi-state outbreak of Salmonella javiana and Salmonella oranienburg infections due to consumption of contaminated cheese. JAMA 1992;268:3203-7.

15. Hedberg CW, Levine WC, White KE, Carlson RH, Winsor DK, Cameron DK, MacDonald KL, Osterholm MT, the Investigation Team. An international outbreak of shigellosis associated with consumption of food served by a Minnesota-based commercial airline. JAMA 1992;288:3208-12.

16. Hedberg CW, David MJ, White KE, MacDonald KL, Osterholm MT. Role of egg consumption in sporadic Salmonella enteritidis and Salmonella typhimurium infections in Minnesota. J Infect Dis 1993;167:107-11.

17. Hedberg K, White KE, Hedberg CW, Brandriet J, Osterholm MT, MacDonald KL. Persistance of Chlamydia complement-fixation antibody after an outbreak of psittacosis. J Infect Dis 1993;167:502-3.

18. Wood RC, MacDonald KL, White KE, Hedberg CW, Hanson M, Osterholm MT. Risk factors for lack of detectable antibody following hepatitis B vaccination with recombinant vaccines in Minnesota health-care workers. JAMA 1993;270:2935-2939.

19. Ehresmann KR, Hedberg CW, Grimm MB, Norton CA, MacDonald KL, Osterholm MT. An outbreak of measles at an international sports event with airborne transmission in a domed stadium. J Infect Dis 1995;171:679-83.

20. Hedberg K, Osterholm MT, Gabriel LL, Hedberg CW, MacDonald KL. Listeriosis in Minnesota, January 1986 through May 1988. Am J Public Health 1995;85:1293-1294. (Letter)

21. Hennessy TW, Hedberg CW, Slutsker L, White KE, Besser-Wiek JM, Moen ME, Feldman J, Coleman WW, Edmonson LM, MacDonald KL, Osterholm MT, and the Investigation Team. A multistate outbreak of Salmonella enteritidis infections associated with consumption of Schwan's ice cream. N Engl J Med 1996;334:1281-1286.

22. Bender JB, Hedberg CW, Besser JM, Boxrud DJ, MacDonald KL, Osterholm MT. Surveillance for Escherichia coli O157:H7 infections in Minnesota by molecular subtyping. N Engl J Med 1997;337:388-394.

23. Hedberg CW, Savarino SJ, Besser JM, Paulus C, Thelen VM, Meyers L, Cameron DN, Kaper J, Osterholm MT and the Investigation Team. An outbreak of foodborne illness caused by Escherichia coli O39:NM, an agent not fitting into the existing scheme for classifying diarrheogenic E. coli. J Infect Dis 1997;176:1625-8.

24. Ehresmann KR, White KE, Hedberg CW, Anderson E, Korlath JA, Moore KA, Osterholm MT. A statewide survey of immunization rates in Minnesota school age children: implications for targeted assessment and prevention strategies. Pediatr Infect Dis J 1998;17:711-16.

25. Smith KE, Besser JM, Hedberg CW, Leano FT, Bender JB, Wicklund JH, Johnson BP, Moore KA, Osterholm MT, and the Investigation Team. The epidemiology of quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992-1998. N Engl J Med 1999;340:1525-32.

26. Hedberg CW, Angulo FJ, McFarland JW, Besser-Wiek JM, Schell W, Wood RC, Stobierski MG, White KE, Osterholm MT, and the Investigation Team. Outbreaks of salmonellosis associated with eating uncooked tomatoes: Implications for public health. Epidemiol Infect 1999 (In Press)

27. Deneen VC, Hunt JM, Hedberg CW. The impact of foodborne calicivirus disease: the Minnesota experience. J Infec Dis 1999 (In Press)

Reviews, Commentaries and Editorials:

1. Williams DN, Vance JC, Hedberg CW, Foley C, Osterholm, MT. Lyme disease and erythema chronicum migrans in Minnesota. MN Med 1982;65:217-21.

2. Peterson DR, White KE, Hedberg CW. The development of a model disease surveillance system for state health departments. Proceedings of the 1985 public health conference on records and statistics. Hyattsville, MD. 1988:423-7.

3. Goodman RA, Lie LA, Dietch SR, Hedberg CW. Relationship between day care and health care providers. Rev Infect Dis 1986;8:669-71.

4. Hedberg CW, Osterholm MT. Serologic tests for antibody to Borrelia burgdorferi: Another Pandora's box for medicine? Arch Int Med 1990;150:732-3.

5. Hedberg CW, Osterholm MT. Food safety for the 1990s. MN Med 1993;76:33-6.

6. Hedberg CW, Osterholm MT. Outbreaks of food- and waterborne viral gastroenteritis. Clin Microbiol Rev 1993;6:199-210.

7. Hedberg CW, Osterholm MT, MacDonald KL. The changing epidemiology of foodborne disease: A Minnesota perspective. Clin Infect Dis 1994;18:671-672.

8. Hedberg CW. Commentary: physicians and foodborne illness. Infect Dis Clin Pract 1996;5:323-324.

9. Hedberg CW, Hirschhorn N. Annotation: why foodborne disease surveillance is critical to the safety of our food supply. Am J Public Health 1996;86:1075-1076.

10. Hedberg CW. Foodborne disease: how to respond? Med J Aust 1996;165:667.

11. Tauxe R, Kruse H, Hedberg C, Potter M, Madden J, Wachsmuth K. Microbial hazards and emerging issues associated with produce. A preliminary report to the National Advisory Committee on Microbiologic Criteria for Foods. J Food Prot 1997;60:1400-1408.

Book Chapters

1. Osterholm MT, MacDonald KL, Hedberg CW. Lyme disease. In Bacterial Infections of Humans. 2nd ed. Evans and Brachman, eds. p403-23, 1991.

2. Osterholm MT, Hedberg CW, MacDonald KL. The epidemiology of infectious diseases. In Principles and Practice of Infectious Diseases. 4th ed. Mandell, Douglas and Bennett, eds. p158-68, 1994.

3. Moore KA, Hedberg CW, Osterholm MT. Lyme Disease. In Bacterial Infections of Humans. 3rd ed. Evans and Brachman eds. p437-458, 1998.

4. Osterholm MT, Hedberg CW, Moore KA. The epidemiology of infectious diseases. In Principles and Practice of Infectious Diseases. 5th ed. Mandell, Douglas and Bennett, in press.

Craig Hedberg, Associate Professor