October 14, 2002
Operative IV - Section 2
University of Minnesota School of Dentistry
Russell Dylla, Lucas Eichmeyer, Ben Fenger, Adam Forster
Erin Gannon, Ryan Francis, David Gilmer, Steve Graber, Jeremy Gross
Table of Contents
Plan
The primary problem of interest is what modalities are available in a
lesion specific approach to mild and moderate carious lesions. In the
majority of cases, it is the standard to remove the area of decay and
fill it with a variety of different restorative materials. The
alternatives for treatment are numerous, as scientific researches in the
area of restorative materials has expanded. Such research has currently
been leading into a lesion specific approach. Based on this idea, such
possibilities include composite, glass-ionomer, air abrasion,
sono-abrasion, and lasers. The primary plan is to evaluate the
materials and methods available to the practicing dentist for treatment
of a carious lesion. The hypothetical lesion in this review will focus
on a mild to moderate lesion that has been diagnosed as extending
through enamel and into the dentin of the tooth. Our clinical question
is: What options/alternatives are present for treatment of a mild to
moderate lesions, and what are their properties that may be of interest?
The hope of this review is to evaluate the different treatment options,
and come to a position on the use or nonuse of each.
Introduction
The diagnosis and treatment of a carious lesion in an environment as
harsh as the oral cavity can be a very difficult process. The operator
must first identify the lesion and determine the degree of progression.
Then decide if it should be treated and if so, how to treat it.
Presently, there are varying trains of thought on how to treat lesions
of different severity. This paper reviews the mild to moderate carious
lesion; it's diagnosis, various treatments, and eventual prognosis. Our
aim is to provide a detailed assessment of the role of the dentist in
caring for the mild to moderate dental lesion.
A mild carious lesion, or incipient lesion, is commonly referred to as a
white spot lesion. The tooth surface is usually smooth but with a chalky
white color due to the initiation of decalcification in the underlying
enamel matrix. The moderate, or intermediate, lesion is a precavitated
lesion that has a rough surface with slightly deeper discoloration due
to repeated remineralization and demineralization cycles. Diagnosis of
these precavitated lesions is very difficult and a variety of methods
are often used clinically. Radiographically, these lesions usually
appear as small interproximal notches, and can be nearly completely
undetectable within the pits and fissures of an occlusal surface. One
study in particular (Verdonschot et al. 1992) found visual
identification of incipient and precavitated lesions to be only 13%
specific and the use of explorers to add no accuracy to the diagnosis.
The diagnosis of precavitated lesions is quite difficult and unreliable
(Charland et al. 2002). Therefore it is often recommended to observe the
lesion and implement remineralization therapy before performing any
invasive procedures (Mount and Ngo 2000). If this does not resolve the
lesion, a very conservative and lesion specific preparation and
restoration can be implemented. Although this is the hope of dentistry
to be conservative, it is not always the case. For this particular
review we will be focusing on the lesion specific approach and attempt
to deviate from the standard G.V. Black criterion. In order to better
understand the lesion specific approach it is only necessary that we
briefly discuss concepts about treatment of the lesion in question.
Then the different modalities for intervention will be considered.
Past, Present, and Future
Dental caries is by no means a new phenomenon. As long as there have
been teeth, it is only plausible to conclude that there have been
cavities as well. The means by which carious lesions are treated,
however, has evolved with time. In ancient times, teeth suffering from
mild to moderate caries were not restored or dealt with at all. Rather,
it was not until the caries reached a severe state that the teeth were
"treated." Treatment usually consisted of extracting the affected tooth
(Hume 1998). This was the case until 1728, when Fauchard began cleaning
out the decayed area of a tooth as an alternative to extraction (Hume
1998). Metal plugs made of gold, tin, or lead were then placed in the
newly excavated area. G.V. Black may have used this idea as a template
for the "extension for prevention" theory of tooth restorations.
According to his theory substantial amounts of healthy tooth tissue were
removed to provide the correct cavity form for the placement of amalgam
(Hume 1998). Not until recently composite restorative materials have
allowed for restorative designs that provide for the "increased
conservation of tooth structure, increased resistance to subsequent
fracture, and therefore improved patient health" (Hume 1998). Thus,
composites are currently one of the major areas of research in
dentistry.
Another new area of current dental research is to generate synthetic
tooth structure that mimics natural tissue. This synthetic structure
could then be used as a treatment option for mild to moderate carious
lesions. The term biomimetic means to mimic biology, and in this
scientific context it deals with the study of biological structures,
functions, and synthetic pathways (Slavkin 1996). This field of
research has had mixed success. Many researchers have tried to employ
the use of multi pluripotent stem cells to reach this goal. These human
stem cells are typically harvested from dental pulp and cultured in
laboratories (Krebsbach 2002). At which time they are then loaded on a
synthetic scaffolding that allows for their stable transfer into the
target, where they can grow to form dentin (Krebsbach 2002). This has
been shown to work on immunosuppressed mice in laboratory settings, but
has yet to be tried in humans. Ideally, stem cells will be harvested
from the same host in which they'll be replanted to regenerate the
tissue desired in the tooth. This would help to avoid a graft vs. host
response or any other immune response (Krebsbach 2002). The
identification of genes and gene products (enamelin, amelogenin,
ameloblastin) associated with enamel formation gives hope that enamel
regeneration is perhaps on the horizon (Slavkin 1996). Not only does
this area of research show promise, so does that of conservation of
tooth structure not seen with the placement of dental amalgams.
In all, we have progressed from extraction (total loss of all tooth
structure) to amalgams (loss of some sound tooth structure) to
composites (lesion specific preparations) to potential tooth
regeneration (the future).
Dental Amalgams
The history of dental amalgam restorations is a long one. Tin-mercury
dental restorations were reportedly used in China in A.D. 600. In the
1830's, France and the western world were introduced to silver-mercury
restorations. In 1896, Dr. G.V. Black published a scientific report
advocating the use of amalgams for dental procedures. The dental
profession eventually universally accepted amalgams, not many years
after the report by G.V. Black was published (Dodes 2001).
G.V. Black listed seven steps of cavity preparation to follow when using
amalgam: outline form, resistance form, retention form, convenience
form, caries removal, finish of the enamel walls, and cleansing of the
cavity. Amalgam as a material requires a certain thickness to be
fracture resistant; therefore, preparations are to be at least 0.5mm
into tooth dentin to allow for the necessary bulk. The pulpal floor of
the preparation should be flat to resist the occlusal stresses and
forces from the condensation of amalgam. In class I and II amalgams,
the occlusal walls at the marginal ridges are to be divergent as to not
undermine or weaken the marginal ridges, while the walls around the
triangular ridges are to be convergent. This ideal helps to lead to the
retention of the amalgam filling by overextending beyond the outline of
the lesion. In class II preparations the proximal box is to have a
gingival seat that is perpendicular to the long axis of the tooth to
resist occlusal stresses, and have the buccal or lingual wall under the
functional cusp slightly convergent to provide retention of the amalgam
against gingivoocclusal displacement. Again, this concept requires that
there be extension beyond the borders of the lesion for the sole purpose
of bulk and retention of the amalgam. In the class V restoration, a
slot or box preparation must be created to retain the amalgam,
increasing the amount to tooth structure removed. Also, line angle
retention is often added into the proximal box in class II preparations
to provide mechanical lock (retention) to the amalgam in a mesial or
distal direction. Finally, undermined enamel must be removed in these
preparations to decrease the chance of fracture at the cavosurface
margin (Hill et al. 2001). All of the above requirements are based on
"extension for prevention" which has been an integral part of dentistry
for over 100 years (Osborne and Summitt 1998). In addition, all
criterion stated above require extension of the tooth preparation beyond
the lesion specific site.
Webb presented one of the earliest references to "extension for
prevention" in 1881. He stated that to prevent decay, margins of enamel
should be free from contact with an adjacent tooth. In 1891 G.V.
Black's idea of "extension for prevention", was to provide extension of
the preparations to the facial and lingual line angles to bring about
"self-cleansing" margins. Black also concluded that it was appropriate
to extend preparations through fissures to allow cavosurface margins to
be on non-fissured enamel. Based on this review it can be observed that
a common theme runs true, extension beyond the lesion to simply
facilitate the use of the dental material. By the 1950's, challenges to
these ideas were made, and since that time, narrower and more
conservative preparations have been made. With this change in
preparation theory, preparations that extend into dentin can be confined
to areas of actual dentin caries. G.V. Black's first step of cavity
preparation, establishing outline form, can now be accomplished by
removal of carious dentin and the overlying, unsupported enamel. This
concept of decreased extension, along with treatment of active caries
only when it has penetrated the dentin radiographically, is based on
minimal intervention and is currently "state-of-the-art" in operative
dentistry. Today's challenge to dental professionals is to maintain as
much sound tooth structure as possible, rather than extending
preparations into sound tooth structure. This challenge is what has
caused so much controversy over the use of dental amalgams in dentistry
(Osborne and Summitt 1998).
Today, the use of amalgams is often questioned for many reasons. First,
the esthetics of amalgams is far from superior when compared with other
restorative materials. Most patients do not prefer silver colored
fillings in their anterior teeth or even in their pre-molars. Second,
amalgam restorations contain mercury, which leaches into the oral cavity
over time. Many studies have been done to determine if detrimental
health effects occur due to the leached mercury. No health problems can
be directly linked to amalgam restoration, but many consumers are still
skeptical (Dodes 2001). Third, amalgam does not adhere to tooth
structure. Therefore it must rely on cavity design for retention, and
this leads to larger preparations. Furthermore, amalgams cannot
increase the fracture resistance of prepared teeth unless complete
cuspal coverage is provided or an amalgam pin technique is used. Even
today amalgam pin use is questioned. Hence, teeth that have been
restored with class I or II amalgams have an increased chance of cuspal
fracture. Current advancements in amalgams, such as the use of adhesive
bonding agents with amalgam, may help to provide support to weakened
cusps and improve resistance to fracture. Despite amalgams several
disadvantages, their longevity is similar or slightly superior to
composite resin restorations. Composites, while considered more
"lesion-specific" than amalgams, show problems such as increased wear,
polymerization shrinkage, long-term microleakage, and greater technique
sensitivity than amalgams. These disadvantages of composites are what
may keep amalgam restorations from disappearing in dental offices
(Santos and Meiers 1994). Before a sound conclusion can be made a review
of resin composite restorations must be made.
Resin Composite Considerations
Mild to moderate dental lesion can pose several issues for the dental
practitioner. The ability of the tooth to render itself vital by way of
inhibiting the lesion from entering the pulp chamber is the primary goal
when treating this type of lesion. In order to accomplish this the
clinician must remove all decay and restore the tooth to an optimal
condition that not only stops the lesion from entering the pulp, but
also inhibits the process and progression of secondary caries. It is
agreed upon that the clinical diagnosis of secondary caries is the most
common reason for replacement of restorations in general practice
(Gordan et al 2002). Of course, this is highly dependent upon the type
of restorable material used. The scope of this section concentrates on
the use of composites, primarily packable, and its use for restoring the
mild to moderate dental lesion.
Despite excellent esthetics and vast improvements in the bonding
processes; polymerization shrinkage, different coefficients of thermal
expansion, and wear resistance of resin-bonded composites prevent these
materials from becoming lifelong restorations (Gordan et al 2002). The
aforementioned factors in conjunction with cavity depth can greatly
affect the success of an extensive composite restoration.
When one considers a mild to moderate dental lesion, it is generally
considered the lesion extends well into the dentin. The depth of the
lesion can have great impact on the success of a composite restoration.
Yoshikawa et al agree that it is difficult to obtain high bond strengths
to deep dentin (1999). Although our scope doesn't focus on adhesion,
this is a crucial process in determining the ultimate outcome of a
composite restoration. Due to the vast number and larger size of the
dentinal tubules a high content of water is present, decreasing the
potential for high bond strength. The lack of a secure bond can
increase the opportunity for secondary caries to progress and jeopardize
the success of treatment.
Another issue involved with resin composites is polymerization. The
greater the volume of composite to be polymerized is proportional to a
greater amount of shrinkage (Yap 2000). As a general rule,
polymerization should be performed in increments of 2.0mm. This
recommendation is especially true for cavity preparations with four or
five walls. Yap and other researchers have noted that at depths greater
than 2.0mm poor polymerization resulted. Therefore, larger lesions deep
into dentin require more polymerization and produce larger stresses on
the adhesive bonding agents. Consequently, this may result in secondary
caries due to potential for bacterial ingress along the margin of the
restoration and the remaining tooth structure.
Yet another interesting study included using cavity depth as a variable
versus the amount of enamel loss at the cavosurface margin upon removal
of composite restorations. Gordan et al (2002) found that the deeper
the cavity, the greater the loss of tooth structure at the cavosurface
margin. A possible explanation could be due to the higher bonding
strength adhesives have with enamel versus dentin.
Resin bonded composites are highly superior to other direct restorable
materials in regards to the cavity design. Studies have indicated that
cavity configuration is of minor importance when using composites due to
the bond strength to tooth structure. Therefore more attention may be
laid on removing the carious tooth structure, rather than exact
preparation designs dictated by materials. Although, depth may
compromise bond strength as found by Yoshikawa et al (1999), the design
is secondary to depth and conservative preparations can lead to greater
conservation of healthy tooth structure. Despite the various
disadvantages of restoring larger lesions with composite, this benefit
of composite restorations is what attracts many clinicians to the use of
composite as a direct restorative material. Another variant of
composite is a flowable composite and glass-ionomer.
Flowable Composites and Glass-Ionomers
In dentistry today, the common patient demands both functional use and
esthetic satisfaction of their dental restorations. "The increasing
attractiveness of tooth-colored restorations has promoted research in
this particular area of operative dentistry during the last few years"
(Frankenberger, et al. 2002). Flowable composites and glass-ionomers
are on the cutting-edge of dentistry right now and it is the hope of
many dentists that such materials can be proven competent and strong.
Currently, flowable composites and glass-ionomers are being used to
restore mild to moderate carious lesions. The PRR (preventative resin
restoration) is an example of a mild restoration that both of these
materials are being used for. The questions that many dentists have
are: how good is the bond to enamel and dentin of these materials and
how durable are these materials?
A significant advantage of virtually all adhesion dental procedures is
conservation of tooth structure. Flowable composites are commonly used
to penetrate small pits and fissures in teeth, avoiding the need to
remove additional tooth structure to accommodate other filling
materials. Containing fluoride, these agents are ideally suited as
decay prevention sealants, especially for children. Other uses for this
material include shallow occlusal restorations, sealants, class I
restorations on primary teeth, mild class II restorations on primary
teeth, temporary restoring of fractured cusps, some smaller class IV
restorations and class III and V restorations when the restoration is
isolatable. Studies have shown that flowable composites have yet to
prove their ability to adhere to enamel or dentin on their own. Bonding
agents still must be utilized to achieve this adhesion. Flowable
composites or low viscosity composites show different properties
compared with hybrid or packable composites and are indicated for the
restoration of minimally invasive cavity preparations. Also, they are
indicated as a stress-breaking base material under packable composites
because of their lower elastic modulus. Until newer flowable composites
can be developed, packable composites are preferred as the universal
solution for restorative needs in the majority of cases.
Glass-ionomers have been around for over 20 years in dentistry.
"Glass-ionomers have certain advantageous properties, such as sustained
fluoride release, chemical bonding to tooth substance, and pulpal
biocompatibility, but they are not considered to possess the adequate
mechanical properties that qualify them for general use as permanent
restoration materials in stress-bearing posterior areas" (Manhart et al.
2002). Many of these restorations fail because of their low mechanical
strength. In a literature review study conducted on papers written from
1988 to 2000, it was discovered that the annual failure rates of
posterior glass-ionomer restorations range within 1.9% to 14.4%. It has
been also reported that most glass-ionomer restorations have only a
median longevity of three years, including all cavity classes placed by
general practitioners. Glass-ionomers have several uses including
"luting cement; restorative cements: restorative aesthetic-auto cure,
restorative aesthetic-resin modified, restorative reinforced; and lining
and base cements" (Mount 1998). Each type has its own respective
advantages. Luting cements have an ultimate fine thickness, which is
the most appealing characteristic. Some restorative cements have
esthetic advantages, while others have high physical properties (losing
their esthetic advantages). Lining and base cements obviously line and
base the tooth preparation. The problems now found with glass-ionomers
are the actual release of fluoride and the decrease in fluoride release
over time. Products tested in 2001(Glass-ionomer Ketac-Fil, Fuji II,
and Ketac Silver) showed "a strong initial rate of release which
decreased over time until, it reached a relatively steady state rate
after two weeks" (Hattab, et al. 2001). This same study showed that
fluoride release was significantly less in artificial saliva than in
ionized water. Many of the products do not release the amount of
fluoride that they claim to release.
Preventative resin restorations are restorations that are used to
prevent and destroy incipient lesions in the enamel or rarely to the DEJ
(dentin-enamel junction). When extended into the dentin the restoration
is no longer considered a PRR. A PRR can be placed anywhere on a tooth,
including: pits, fissures, abnormal anatomic structures, or any other
bacteria collecting area on a tooth. The idea of these restorations is
to prevent mild to moderate cavitation of the bacteria prone or infected
tooth. Both flowable composites and glass-ionomers are now being noted
as viable materials for patients with small approximal lesions and
intact marginal ridges without cracks or opacities, otherwise known as
class I or II tunnel restorations. The tunnel preparation technique is
a more conservative approach for the treatment of approximal lesions
than that of G.V. Black's classic principles. The longevity of these
dental restorations is dependent on many different factors, including
those related to materials, the dentist, and the individual patient. It
is to be expected that the use of improved direct restorative materials
will provide excellent longevity even in stress bearing situations. Now
with the understanding of the sedative fillings it is necessary that the
mechanisms for removal of carious dentin and enamel be considered.
Alternative Excavation Techniques
Dental air abrasion is a process similar to sandblasting. The
instrument uses pressurized air and an abrasive dust (usually aluminum
oxide) (Banerjee 2000). The stream of dust and air is aimed at the
tooth to remove tooth structure. The application of air abrasion, for
dental use was first studied in 1940 by Dr. Robert Black. The first
dental air abrasion unit was introduced by The S.S. White company in
1951. Using air abrasion was a welcomed alternative to the loud belt
driven handpieces of the 1940's. The procedure also increased patient
comfort because it produced less heat and vibration than the handpieces
(White 2000).
The procedure quickly fell out of favor for several reasons. The first
reason is that the preparations made with the air abrasion unit are
smooth and flowing, which does not lend itself to material specific
preparations. The second reason is that suction was not very good in
the 1940s so the machine made a mess in the clinic operatory. Third,
dentists were able to do preparations faster with the new air turbines
of the 1950s (White 2000).
Air abrasion has made a comeback. In 2000 18% of general practitioners
used air abrasion. The resurgence of the air abrasion procedure can be
attributed to the availability of lesion specific composites and the
attempt to conserve tooth structure. Air abrasion is indicated as a
method for removal of caries and restoration preparation. There are
several positive aspects of air abrasion usage for mild to moderate
caries. One reason is that the majority of preparations done with air
abrasion can be done without anesthesia. White found that 85-90% of
patients surveyed did not request anesthesia for air abrasion procedures
in the dentin (White 2000). Air abrasion produces cavity margins that
are almost imperceptible (Setien 2001). Also, air abrasion is good for
anxious patients because it is much quieter than air turbine drills
(White 2000).
As with many novel dental procedures, there are disadvantages to using
air abrasion. One disadvantage is that air abrasion with aluminum oxide
does not effectively remove carious dentin. This is because the kinetic
energy of aluminum oxide tends to be absorbed by soft leathery carious
dentin. However, air abrasion does remove sound enamel and dentin,
which can lead to over preparation. Another negative factor is the lack
of tactile ability with the air abrasion. This is because the nozzle
does not touch the tooth during the procedure (Banerjee 2000).
Additionally, air abrasion should not be used near amalgam fillings
because it releases 4 times the OSHA limit of mercury vapor when used
for one minute on amalgam (White 2000). In light of these negative
factors, air abrasion is not the method of choice for excavation of mild
to moderate carious tooth structure. Soft decay is best removed with a
slow speed and a large round bur or a spoon excavator (Banerjee 2000).
Sono-abrasion is essentially a modified cavitron with a diamond-coated
tip. This device is called Sonicsys and was recently developed by KaVo
(Banerjee 2000). Setien (2001) found that the Sonicsys weakened enamel
rods causing cracks in the enamel adjacent to a preparation in 11 out of
18 trials.
Er:YAG (erbium: yttrium-aluminum-garnet) lasers have been investigated
for removal of hard tissue. At the present date there are many problems
with this technique. One problem is that the laser tends to heat up the
pulp causing irritation or permanent damage (Banerjee 2000). An
additional problem with the laser rapidly heating the tooth is that it
causes microexplosions in the dentinal tubules. These microexplosions
cause cracks and fractures in the dentin. In addition to these problems
the lasers are very expensive (Setien 2001).
Several novel techniques for caries excavation/preparation have been
discussed. As table 1 indicates, rotary burs are the most effective for
removing all types of tooth structure. After reviewing several papers
on these instruments, it is this author's opinion that rotary burs and
spoon excavators should be considered the gold standard for caries
excavation/preparation. Air abrasion may have a role in dentistry for
anxious patients. Without further development Sono-Abrasion and lasers
have no part in dentistry for caries excavation/preparation.
Concluding Thoughts
Restoration of carious lesions in the future is progressing to improve
upon the materials and methods that dentists currently use. For
example, it has recently been shown that amalgam restorations designed
with rounded internal line angles resulted in less tooth and cusp
fractures (Hume 1998). This idea is contradictory to past and current
teachings that sharp internal line angles are the ideal. As amalgam
becomes phased out of many dental practices, the general shift in
dentistry is toward restoring mild to moderate carious lesions with
composite tooth bonding materials. Being in the active stage of
development, composite materials and techniques for application are
subject to change and improvement. Strides for improvement should be
made to reduce moisture sensitivity of these materials in the future.
This would help limit the amount of operator error involved in
placement. Future adhesive restorative materials may "incorporate
biomimetic intermediate-strength domains that can undergo stepwise
reversible unfolding in response to varying functional stress levels
before ultimate catastrophic failure of the adhesive joint occurs.
These domains may also re-establish folded configurations on stress
relaxation, making the adhesive both strong and tough" (Tay 2002).
Another area in which dental adhesives could advance is with the
addition of fluorescent biosensors to sense changes in the pH around
leaking restorations (Tay 2002). In other words, adhesives of the
future will be smarter and be better able to adapt to the stresses of
their surroundings. This should result in restorations that last longer
and hold up better in the oral cavity.
Restorative dentistry could head in any one of many directions in the
future, but a few things are certain and a few definite trends exist.
Treatment has been heading towards more and more conservative means of
dealing with carious lesions. Prevention of caries is being stressed
through better education and more widespread fluoridation tactics.
Fortunately, less unnecessary tooth destruction is occurring. So where
do we go from here? Is it possible to progress even further and restore
carious lesions without having to remove tooth structure at all?
Undoubtedly, research has shown that the restorative materials used on a
daily basis will continue to get better. It seems very likely that in
the near future we will have a method of tooth regeneration that will
forever change the face of dentistry. In addition, the methods and
instruments to remove dental caries are changing. With all of the
options available today it is imperative that there be adequate research
and knowledge available to the practitioner so that treatment decisions
can be made based on sound evidence. These certainly are exciting and
evolving times in the world of restorative dentistry!
The relative ability of various excavation techniques to remove tooth tissue (Banerjee 2000)
Method
Sound Enamel
Sound Dentin
Carious Enamel
Carious Dentin
Hand Excavators
-
-
+
++
Rotary Burs
+++
+++
+++
+++
Air-Abrasion
+++
+++
++
+
Sono-Abrasion
-
+
+
++
Lasers
+
+
+
+